Nichelle Nichols (born Grace Dell Nichols) is an American actress, singer, and voice artist best known for her portrayal of Nyota Uhura in Star Trek: The Original Series, and its film sequels. Nichols' portrayal of Uhura was ground-breaking for African American female characters on American television.

From 1977 to 2015, Nichols volunteered her time to promote NASA's programs, and to recruit diverse astronauts, including women and ethnic minorities. As of 2021, Nichols is one of four surviving members of the original cast of Star Trek, the others being William Shatner, George Takei and Walter Koenig.

Her break came in an appearance in Kicks and Co., Oscar Brown's highly touted but ill-fated 1961 musical. In a thinly veiled satire of Playboy magazine, she played Hazel Sharpe, a voluptuous campus queen who was being tempted by the devil and Orgy Magazine to become "Orgy Maiden of the Month". Although the play closed after a short run in Chicago, Nichols attracted the attention of Hugh Hefner, the publisher of Playboy, who booked her for his Chicago Playboy Club.

She also appeared in the role of Carmen for a Chicago stock company production of Carmen Jones and performed in a New York production of Porgy and Bess. Between acting and singing engagements, Nichols did occasional modeling work.

In January 1967, Nichols also was featured on the cover of Ebony magazine, and had two feature articles in the publication in five years. Nichols toured the United States, Canada and Europe as a singer with the Duke Ellington and Lionel Hampton bands. On the West Coast, she appeared in The Roar of the Greasepaint and For My People and she garnered high praise for her performance in the James Baldwin play Blues for Mister Charlie. Prior to being cast as Lieutenant Uhura in Star Trek, Nichols was a guest actress on television producer Gene Roddenberry's first series The Lieutenant (1964) in an episode, "To Set It Right", which dealt with racial prejudice.

Nichols has released two music albums. Down to Earth is a collection of standards released in 1967, during the original run of Star Trek. Out of This World, released in 1991, is more rock oriented and is themed around Star Trek and space exploration.

After the cancellation of Star Trek, Nichols volunteered her time in a special project with NASA to recruit minority and female personnel for the space agency. She began this work by making an affiliation between NASA and a company which she helped to run, Women in Motion.

The program was a success. Among those recruited were Dr. Sally Ride, the first American female astronaut, and United States Air Force Colonel Guion Bluford, the first African-American astronaut, as well as Dr. Judith Resnik and Dr. Ronald McNair, who both flew successful missions during the Space Shuttle program before their deaths in the Space Shuttle Challenger disaster on January 28, 1986. Recruits also included Charles Bolden, the former NASA administrator and veteran of four shuttle missions, Frederick D. Gregory, former deputy administrator and a veteran of three shuttle missions and Lori Garver, former deputy administrator. An enthusiastic advocate of space exploration, Nichols has served from the mid-1980s on the board of governors of the National Space Institute (todays National Space Society), a nonprofit, educational space advocacy organization.

In late 2015, Nichols flew aboard NASA's Stratospheric Observatory for Infrared Astronomy (SOFIA) Boeing 747SP, which analyzed the atmospheres of Mars and Saturn on an eight-hour, high-altitude mission. She was also a special guest at the Jet Propulsion Laboratory in Pasadena, California, on July 17, 1976, to view the Viking 1 soft landing on Mars. Along with the other cast members from the original Star Trek series, she attended the christening of the first space shuttle, Enterprise, at the North American Rockwell assembly facility in Palmdale, California. On July 14, 2010, she toured the space shuttle simulator and Mission Control at the Johnson Space Center.

Nichols' work with NASA is given significant focus in the documentary Woman in Motion about her life.

Nichols had one child, Kyle Johnson, who was born August 14, 1951.

Nichols was diagnosed with dementia sometime in 2018. She subsequently announced her retirement from convention appearances.

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